Endocrine Abstracts

The vast majority of thyroid cancers are solid. Predominantly cystic tumors occur in <3% cases. Guidelines report as US characteristics consistently associated with a higher risk of malignancy eccentric position of the solid component, acute angle interface and microcalcifications and as less robustly associated lobulated margins and increased vascularity of the solid portion. We reviewed the US characteristics of predominantly cystic papillary carcinomas confirmed on hist...

A personalized patient treatment regimen for endogenous Cushing’s syndrome (CS) should be developed by a specialized multidisciplinary team, taking patient values and preferences into consideration. Comorbidities, which may compromise patient health and QoL need to be addressed, in many cases concomitant with or even before CS-specific treatments to restore eucortisolemia. Treatment of endogenous CS is initially primarily surgical and aims at complete resection of the und...

Primary thyroid lymphoma accounts for <5% of thyroid malignancies. The most common (up to 70%) and clinically aggressive sub-type is non-Hodgkin’s B-cell lymphoma. Mucosa-associated lymphoid tissue (MALT) lymphoma is less common (up to 30%) and clinically more indolent. Females are more frequently affected than males (4-8:1) with onset in 6th and 7th decades. A strong association with Hashimoto’s disease (>90%) is recognised. A 66 year old male presented with...

Introduction: Glucocorticoids, even endogenous or exogenous, suppress the inflammatory response therefore they are the most preferred treatment options in inflammatory diseases. Persistent hypercortisolism induces lymphopenia and lymphoid tissue atrophy. Excessive endogenous hypercortisolism might mask the active inflammatory disease. Rebound immune modulation may occur after Cushing’s syndrome (CS) remission, leading to the new onset of autoimmune diseases.<p class="...

Introduction: Acromegaly is, in most cases, caused by growth hormone (GH) -secreting pituitary adenomas that lead to characteristic phenotypical changes. Its association with emty sella (ES) has been described and different theories has been given to explain such situation. Moreover, patients with acromegaly often develops different pathologies of the thyroid gland, however, the occurrence of grave’s disease (GD) is quite a rare situation. Here we report a case of a pati...

Introduction: Cushing’s disease (CD) is reported in 60-70% of all patients with Cushing’s syndrome (CS), but occurs only in approximately 33% of the reported CS cases in pregnancy. Nevertheless, despite its rarity, pregnancy in patients with CS can be troublesome because of the risk of maternal-fetal complications.Observation: A 28-year-old female patient was referred to our endocrinology department for a suspected CS with morphological alter...

Background: Thyroid hormone has an important role for skin growth and development. Alopecia is one of the clinical feature of autoimmune hypothyroidism or systemic autoimmune diseaseCase IllustrationA 18-year-old Indonesian woman presented with alopecia universalis. It started with a patchy hair loss which then progress to all of her body. At the age of 15 she had complaints of neck enlargement, palpitation, weight loss, and heat i...

The diagnosis of Cushing’s syndrome (CS) is based primarily on diagnostic tests evaluating the cortisol response to dexamethasone suppression. Tests based on oral administration of dexamethasone may be compromised by poor compliance. We evaluated the diagnostic accuracy of a novel intravenous dexamethasone suppression test (IDST). The test is performed by intravenous (iv) bolus injection of 8 mg dexamethasone, with blood cortisol determinations made before injection, then...

Quality life satisfaction is important for personal resources analysis and perspectives for coping with ilness.The aim of the study was to present a psychological portrait of a woman with Turner’s syndrome (TS) and assessing perspectives for increased well-being of such patients. The study concerns psychological aspects of TS women’s own assessment of their health and illness.The area of interest was:<p class="...

Introduction: Pro-opiomelanocortin (POMC) is a precursor polypeptide which is cleaved to make adrenocorticotrophic hormone (ACTH) in the anterior pituitary. It is activated in Cushing’s disease. Current therapies for Cushing’s disease are inadequate. RNA interference (RNAi) allows highly specific and effective suppression of gene expression by use of short interfering RNAs (siRNAs).Method: In the current study we employed custom designed siRNAs...